Sketchy pharm: a midsummer night’s diphenhydramine (H1 receptor antagonists

beehive: histamine sequestered inside the granules of mast cells
‘Q’ dandelion: H1 histamine receptor is coupled to Gq protein (mediates allergic inflammation)
honeypot with 2 ‘S’ handles: H2 histamine receptor is coupled to Gs protein
golden gastric honey: H2 histamine receptor mediates gastric acid secretion
dripping nose sap: histamine increases nasal and bronchial mucus production (H1 receptor activation)
dripping vascular sap: histamine increases vascular permeability (H1 receptor activation) –> urticaria or hives
constricted lung branch: histamine causes constriction of bronchial smooth muscle (H1 receptor activation)
brain tree: histamine functions as a neurotransmitter from non-mast cell (H1 receptor regulates sleep and arousal and neuroendocrine regulation)
bee swatter: H1 receptor blocker (antihistamine) treats allergy
dragonfly fairy: diphenhydramine and dimenhydrinate (1st generation H1 receptor blocker)
color fairy: chlorpheniramine (1st generation H1 receptor blocker)
fairy cuiSINE: hydroxyZINE, mecliZINE, promethaZINE (1st generation H1 receptor blockers)
fairy dust and dander: histamine mediates type-1 allergic reaction –> hives, allergic rhinitis (H1 receptor blockers are first line therapy)
seasick fairy sailors: 1st-generation H1-blockers treat vestibular nausea or motion sickness (lipophilic –> enter CNS –> act on vestibular system and brainstem)
current by the brain: 1st gen H1 receptor blockers easily cross bbb
sleeping under brain tree: 1st gen H1 blockers cause drowsiness by interfering with histamine neurotransmission (lipophilic –> cross BBB–> central effects), e.g. diphenhydramine can be used to treat insomnia
antimuscarinic tea party: 1st generation H1 blockers antagonize peripheral and central muscarinic receptors (e.g. pupillary dilation, dry mouth, urinary retention, constipation, exacerbation of glaucoma, and delirium)
falling “extra parking” cone: 1st-generation H1-blockers treat extrapyramidal side effects caused by antipsychotics, e.g. acute dystonia (antimuscarinic effects re-establish dopaminergic cholinergic balance)
cut smiley face cake: 1st gen H1 blockers antagonize serotonin receptors in the CNS
Stuffed fairy: 1st-gen H1 blockers stimulate appetite and weight gain (anti- serotonergic effects)fainted fairy: 1st gen H1 blockers cause dizziness and hypotension (anti-alpha-adrenergic effects)
extinguished single alpha candle: 1st-gen H1- blockers antagonize alpha-1 receptor –> dizziness and hypotension
delirious elderly man: 1st gen H1 blockers cause cognitive impairment in the elderly (central antihistamine and antimuscarinic effects)
fox, satyr, and rat: 2nd-gen H1 blockers, fexofenadine, cetirizine, loratidine
fox, satyr, and rat stand outside of brain tree: 2nd gen H1 blockers are less lipophilic –> do not cross BBB –> less sedating (also less antimuscarinic, antiserotonergic, or anti-alpha adrenergic properties)treat allergic rhinits and urticaria for minimal side effects